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research article
Position-flexible elaboration of halogenated heterocycles: Metalated species as key intermediates for synthesis
2007
Halogens, in particular fluorine atoms, are favorite tools to fine-tune the chemical and biological properties of pharmaceutical or agricultural development products. At the same time, such an electronegative substituent can effectively assist the site-selective functionalization of an aromatic or heterocyclic core compound by directing a metal to the targeted position, the metal acting as a harbinger for the definitive substituent. The concept is illustrated by typical examples selected from the carbazole, indole, pyrrole, pyrazole, imidazole, pyridine, quinoline and pyrimidine fields.
Type
research article
Web of Science ID
WOS:000253628300002
Authors
Publication date
2007
Published in
Start page
3096
End page
3102
Subjects
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
July 4, 2012
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