An array of four independent laser traps is combined with a polydimethylsiloxane microfluidic chip to form a very compact system allowing parallel processing of biological objects. Strong three dimensional trapping allows holding objects such as functionalized beads in flows at speeds near 1 mm/s, enabling rapid processing. By pressure control of the inlet flows, the trapped objects can be put in contact with different solutions for analysis purpose. This setup, including a fluorescence excitation-detection scheme, offers the potential to perform complex biochemical manipulations on an ensemble of microparticles. (c) 2007 American Institute of Physics.
Titre
Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip
Publié dans
Review of Scientific Instruments
Volume
78
Numéro
11
Pages
116101-1
Date
2007
Editeur
American Institute of Physics
ISSN
0034-6748
Note
ARCoptix S.A., Neuchatel, Switzerland Copyright 2008, The Institution of Engineering and Technology 9928537 0034-6748 multiple optical trapping microflow manipulation rapid bioanalytics laser traps PDMS microfluidic chip biological objects three-dimensional trapping functionalized beads pressure control inlet flows fluorescence excitation-detection scheme complex biochemical manipulations cell functions
Date de création de la notice
2012-06-20