Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip
An array of four independent laser traps is combined with a polydimethylsiloxane microfluidic chip to form a very compact system allowing parallel processing of biological objects. Strong three dimensional trapping allows holding objects such as functionalized beads in flows at speeds near 1 mm/s, enabling rapid processing. By pressure control of the inlet flows, the trapped objects can be put in contact with different solutions for analysis purpose. This setup, including a fluorescence excitation-detection scheme, offers the potential to perform complex biochemical manipulations on an ensemble of microparticles. (c) 2007 American Institute of Physics.
Keywords: Tweezers ; Systems ; Devices ; Forces ; Cells ; [LAT] ; biochemistry ; biological techniques ; bioMEMS ; cellular biophysics ; fluorescence ; lab-on-a-chip ; microfluidics ; molecular biophysics ; radiation pressure
ARCoptix S.A., Neuchatel, Switzerland Copyright 2008, The Institution of Engineering and Technology 9928537 0034-6748 multiple optical trapping microflow manipulation rapid bioanalytics laser traps PDMS microfluidic chip biological objects three-dimensional trapping functionalized beads pressure control inlet flows fluorescence excitation-detection scheme complex biochemical manipulations cell functions
Record created on 2012-06-20, modified on 2016-08-09