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research article
Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints
2011
Background: The HIV-1 genome is subject to pressures that target the virus resulting in escape and adaptation. On the other hand, there is a requirement for sequence conservation because of functional and structural constraints. Mapping the sites of selective pressure and conservation on the viral genome generates a reference for understanding the limits to viral escape, and can serve as a template for the discovery of sites of genetic conflict with known or unknown host proteins.
Type
research article
Web of Science ID
WOS:000297754800001
Authors
Publication date
2011
Published in
Volume
8
Start page
87
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
June 12, 2012
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