Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Background: The HIV-1 genome is subject to pressures that target the virus resulting in escape and adaptation. On the other hand, there is a requirement for sequence conservation because of functional and structural constraints. Mapping the sites of selective pressure and conservation on the viral genome generates a reference for understanding the limits to viral escape, and can serve as a template for the discovery of sites of genetic conflict with known or unknown host proteins.


Published in:
Retrovirology, 8, -
Year:
2011
Keywords:
Laboratories:




 Record created 2012-06-12, last modified 2018-03-17


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