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research article
Heteroatom Nucleophile Induced C-C Fragmentations to Access Functionalized Allenes
2012
The rich structural and reactivity profile of allenes render them versatile synthetic intermediates. However, application of allenes in organic chemistry is often attenuated by inconvenient methods of preparation. Herein we present an operationally simple route to functionalized allenes from vinyl triflate precursors through a Grob-type fragmentation induced by heteroatom nucleophiles such as water, alcohols, thiols or amines. The fragmentation occurs under mild conditions and is well suited for one-pot or domino processes allowing access to a range of synthetically useful intermediates.
Type
research article
Web of Science ID
WOS:000303851200015
Authors
Publication date
2012
Published in
Volume
66
Start page
205
End page
207
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
June 8, 2012
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