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Measurements of Glycogen Metabolism in the Living Brain

Gruetter, Rolf  
Choi, In-Young
•
Gruetter, Rolf  
2012
Neural Metabolism in vivo

To maintain brain function, the combustion of glucose for the generation of energy (ATP) is essential, yet the brain maintains fuel storage in the form of glial glycogen. Although brain glycogen levels are lower than those in the liver, they exceed the normal free glucose concentration in brain several-fold. Under normoxic conditions, when a partial glucose supply deficit is present, brain glycogen can provide fuel for extended periods of time. Brain glycogen metabolism is active, but comparatively slow, consistent with a role of an emergency fuel with neuroprotective effects. The classical analysis with biochemical means requires tissue extraction; brain glycogen metabolism can be measured directly in the living brain only by 13C NMR spectroscopy. This chapter reviews the insights gained into brain glycogen metabolism in the living brain to-date and reviews potential roles for brain glycogen in the context of neuro-glial metabolism, hypoglycemia and neuroprotection.

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Type
book part or chapter
DOI
10.1007/978-1-4614-1788-0_22
Author(s)
Gruetter, Rolf  
Editors
Choi, In-Young
•
Gruetter, Rolf  
Date Issued

2012

Publisher

Springer

Published in
Neural Metabolism in vivo
Book part title

Cerebral energy metabolism and substrates in vivo

Start page

699

End page

706

Series title/Series vol.

Advances in Neurobiology; 4

Issue
3
Subjects

CIBM-AIT

Written at

EPFL

EPFL units
CIBM  
LIFMET  
Available on Infoscience
May 26, 2012
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/80838
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