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review article
Sirtuins as regulators of metabolism and healthspan
Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.
Type
review article
Authors
Publication date
2012
Published in
Volume
13
Issue
4
Start page
225
End page
38
Peer reviewed
NON-REVIEWED
EPFL units
Available on Infoscience
May 8, 2012
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