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research article
Catalytic Enantiospecific [3+2] Annulation of Aminocyclopropanes with Ketones
The first enantiospecific [3+2] annulation of D-A amino-cyclopropanes with ketones is reported herein (see scheme; Phth = phthaloyl). The reaction is catalyzed by 5 mol % of tin(IV) chloride at -78 °C and gives aminotetra-hydrofurans bearing a C5-quaternary stereocenter in high yield, diastereoselectivity and enantio-specificity.
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Name
CEJ2012-4844GreenAccess.pdf
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openaccess
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3.04 MB
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Adobe PDF
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0bcb2a9cc36ce06ee87169b10f7b7622