Catalytic Enantiospecific [3+2] Annulation of Aminocyclopropanes with Ketones

The first enantiospecific [3+2] annulation of D-A amino-cyclopropanes with ketones is reported herein (see scheme; Phth = phthaloyl). The reaction is catalyzed by 5 mol % of tin(IV) chloride at -78 °C and gives aminotetra-hydrofurans bearing a C5-quaternary stereocenter in high yield, diastereoselectivity and enantio-specificity.


Published in:
Chemistry-A European Journal, 18, 4844-4849
Year:
2012
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 Record created 2012-05-04, last modified 2018-03-17

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