Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.


Published in:
Cancer Cell, 21, 3, 309-322
Year:
2012
Publisher:
Elsevier
ISSN:
1535-6108
Keywords:
Laboratories:




 Record created 2012-04-19, last modified 2018-01-28

External link:
Download fulltext
Publisher's version
Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)