Thalamic control of cortical states

• Published in: Nature Neuroscience (ISSN: 1097-6256), vol. 15, num. 3, p. 370-372
• Nature Publishing Group, 2012

We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.

Keywords: Behaving Mice ; Barrel Cortex ; Responses ; Modulation ; Mechanisms ; Networks ; Dynamics

Reference

• EPFL-ARTICLE-175978
• doi:10.1038/nn.3035
• View record in Web of Science

Record created on 2012-03-29, modified on 2017-05-12