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research article
Nanotopographic Control of Neuronal Polarity
2011
We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent control over the final number and the outgrowth direction of neurites. Taken together, this report provides a novel and promising approach to the rational design of biocompatible textured substrates for tissue engineering applications.
Type
research article
Web of Science ID
WOS:000287049100034
Authors
Ferrari, Aldo
•
Cecchini, Marco
•
Dhawan, Akshay
•
•
Tonazzini, Ilaria
•
Stabile, Ripalta
•
Pisignano, Dario
•
Beltram, Fabio
Publication date
2011
Published in
Volume
11
Start page
505
End page
511
Peer reviewed
REVIEWED
Available on Infoscience
March 26, 2012
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