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research article
The Single-Molecule Mechanics of the Latent TGF-beta 1 Complex
2011
Background: TGF-beta 1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-beta 1 binds to the latent TGF-beta 1-binding protein-1 (LTBP-1), which is part of the extracellular matrix (ECM). Transmission of cell force via integrins is one major mechanism to activate latent TGF-beta 1 from ECM stores. Latent TGF-beta 1 mechanical activation is more efficient with higher cell forces and ECM stiffening. However, little is known about the molecular events involved in this mechanical activation mechanism.
Type
research article
Web of Science ID
WOS:000298440100018
Authors
•
Ramonet, David
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Klingberg, Franco
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•
•
•
Hinz, Boris
Publication date
2011
Publisher
Published in
Volume
21
Start page
2046
End page
2054
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 22, 2012
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