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research article
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies
Novel alpha-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2- hydroxy-1-arylethyl]amine}methyl) pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group = 4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival. (C) 2010 Elsevier Ltd. All rights reserved.
Type
research article
Web of Science ID
WOS:000277083400034
Authors
Bello, Claudia
•
Cea, Michele
•
Dal Bello, Giovanna
•
Garuti, Anna
•
Rocco, Ilaria
•
Cirmena, Gabriella
•
Moran, Eva
•
Nahimana, Aimable
•
Duchosal, Michel A.
•
Fruscione, Floriana
Publication date
2010
Published in
Volume
18
Start page
3320
End page
3334
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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