Radiotherapy Suppresses Angiogenesis in Mice through TGF-beta RI/ALK5-Dependent Inhibition of Endothelial Cell Sprouting

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also their angiogenic capacity. In spite of its clinical relevance, such putative anti-angiogenic effect of radiotherapy has not been thoroughly characterized. We have investigated the effect of ionizing radiation on angiogenesis using in vivo, ex vivo and in vitro experimental models in combination with genetic and pharmacological interventions.


Published in:
Plos One, 5, 6, e11084
Year:
2010
Publisher:
Public Library of Science
ISSN:
1932-6203
Keywords:
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 Record created 2011-12-16, last modified 2018-03-17

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