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review article
Nucleophilic Substitutions of Nitroarenes and Pyridines: New Insight and New Applications
2010
At the beginning of this article an in-depth comparison of electrophilic and nucleophilic aromatic and heterocyclic substitution processes examines their scopes of applicability in a new light. In the subsequent parts, recent progress in the area of halide and hydride displacement from pyridines is highlighted. Particular attention is paid to the leaving group aptitudes of fluoride and chloride, to the effect of 'passive' substituents on the reaction rates, and to the control of the relative reactivity at halogen-bearing 4-versus 2-(or 6-)positions.
Type
review article
Web of Science ID
WOS:000280299200006
Authors
Publication date
2010
Published in
Issue
13
Start page
2111
End page
2123
Peer reviewed
NON-REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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