Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease
 
research article

Environmental Enrichment Reduces Neuronal Intranuclear Inclusion Load But Has No Effect on Messenger RNA Expression in a Mouse Model of Huntington Disease

Benn, Caroline L.
•
Luthi-Carter, Ruth  
•
Kuhn, Alexandre
Show more
2010
Journal Of Neuropathology And Experimental Neurology

Huntington disease (HD) is a fatal neurodegenerative disease with no effective treatment. In the R6/1 mouse model of HD, environmental enrichment delays the neurologic phenotype onset and prevents cerebral volume loss by unknown molecular mechanisms. We examined the effects of environmental enrichment on well-characterized neuropathological parameters in a mouse model of HD. We found a trend toward preservation of downregulated neurotransmitter receptors in striatum of environmentally enriched mice and assessed possible enrichment-related modifications in gene expression using microarrays. We observed similar gene expression changes in R6/1 and R6/2 transgenic mice but found no specific changes in enrichment-related microarray expression profiles in either transgenic or wild-type mice. Furthermore, specific corrections in transprotein-induced transcriptional dysregulation in R6/1 mice were not detected by microarray profiling. However, gene-specific analyses suggested that long-term environmental enrichment may beneficially modulate gene expression dysregulation. Finally, environmental enrichment significantly decreased neuronal intranuclear inclusion load, despite unaffected transgene expression levels. Thus, the therapeutic effects of environmental enrichment likely contribute to decreasing aggregated polyglutamine protein levels without exerting strong effects on gene expression.

  • Details
  • Metrics
Type
research article
DOI
10.1097/NEN.0b013e3181ea167f
Web of Science ID

WOS:000280478800005

Author(s)
Benn, Caroline L.
Luthi-Carter, Ruth  
Kuhn, Alexandre
Sadri-Vakili, Ghazaleh
Blankson, Kwabena L.
Dalai, Sudeb C.
Goldstein, Darlene R.
Spires, Tara L.
Pritchard, Joel
Olson, James M.
Show more
Date Issued

2010

Publisher

Lippincott, Williams & Wilkins

Published in
Journal Of Neuropathology And Experimental Neurology
Volume

69

Issue

8

Start page

817

End page

827

Subjects

Huntington disease

•

In situ hybridization

•

Microarray gene expression profiling

•

Neuronal intranuclear inclusions

•

Neurotransmitter receptors

•

Real-time RT-PCR

•

Receptor binding

•

Transcriptional dysregulation

•

Age-Of-Onset

•

Gene-Expression

•

Transgenic Mice

•

Polyglutamine Aggregation

•

Receptor Expression

•

Mutant Huntingtin

•

Wild-Type

•

Brain

•

Experience

•

Deficits

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LNGF  
Available on Infoscience
December 16, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/75312
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés