Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

New oxathiazinane dioxides have been derived from D- and L-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4'-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane- 3,3-dioxide showed a cytotoxicity of IC50 approximate to 10 mu M. (C) 2009 Elsevier Ltd. All rights reserved.


Published in:
Bioorganic & Medicinal Chemistry Letters, 20, 5353-5356
Year:
2010
Keywords:
Laboratories:




 Record created 2011-12-16, last modified 2018-03-17


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