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research article
Concise Synthesis of Pyrrolidine and Indolizidine Alkaloids by a Highly Convergent Three-Component Reaction
The synthesis of pyrrolidine and indolizidine derivatives through radical carboazidation of alkenes with alpha-iodoketones, followed by reductive amination, is described. When properly substituted, further lactamization afforded pyrrolizidinones in good yield. This carboazidation/reductive amination sequence was efficiently applied to the total synthesis of three different simple alkaloids, including (+/-)-monomorine I.
Type
research article
Web of Science ID
WOS:000288098800021
Authors
Publication date
2011
Published in
Volume
17
Start page
3207
End page
3212
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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