Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography
3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [F-18]FLT in tumor xenografts.
Keywords: [F-18]Flt ; Pet ; FdUrd ; Thymidine synthesis ; Cell proliferation ; Cancer-Patients ; F-18-Flt Pet ; Radiolabeled Iododeoxyuridine ; Ki-67 Immunohistochemistry ; Gastric-Cancer ; Imaging Tracer ; Flow-Cytometry ; Lung-Tumors ; Chemotherapy ; Thymidine ; CIBM-PET
Record created on 2011-12-16, modified on 2016-08-09