Regulation of PGC-1 alpha, a nodal regulator of mitochondrial biogenesis
Mechanisms responsible for energy management in the cell and in the whole organism require a complex network of transcription factors and cofactors. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) has emerged as a master regulator of mitochondrial biogenesis and function, thus becoming a crucial metabolic node. We present an overview of the mechanisms by which PGC-1 alpha is regulated, including the transcriptional regulation of PGC-1 alpha expression and the fine-tuning of its final activity via posttranslational modifications. Am J Clin Nutr 2011; 93 (suppl):884S-90S.
Keywords: Activated Protein-Kinase ; Transcriptional Coactivator Pgc-1-Alpha ; Ppar-Gamma Coactivator-1 ; Fatty-Acid Oxidation ; Skeletal-Muscle ; Hepatic Gluconeogenesis ; Receptor-Gamma ; Nuclear Receptors ; Energy-Expenditure ; Gene-Expression
Record created on 2011-12-16, modified on 2016-08-09