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research article
Total Synthesis of (+/-)-Cylindricine C
2011
A concise synthesis of (+/-)-cylindricine C and its C(13)-epimer is described. Starting from 1-octyne, cylindricine C and 13-epi-cylindricine C were prepared in 11% and 15% yields, respectively. The synthesis involves the preparation of the central tricyclic moiety via a radical alpha-iodoketone carboazidationibis-reductive amination sequence. Inversion of the stereochemistry at C(13) and C(5) was efficiently achieved on late stage intermediates.
Type
research article
Web of Science ID
WOS:000294703900006
Authors
Publication date
2011
Published in
Volume
13
Start page
4774
End page
4777
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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