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  4. Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems
 
research article

Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems

Barry, Nicolas P. E.
•
Zava, Olivier  
•
Dyson, Paul J.  
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2011
Chemistry - A European Journal

A series of large cationic hexanuclear metalla-prisms, Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(donq)(3), Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(doaq)(3) and Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(dotq)(3), composed of p-cymene-ruthenium building blocks bridged by OO boolean AND OO ligands (donq = 5,8-dioxido-1,4-naphthoquinonato; doaq = 5,8-dioxido-1,4-anthraquinonato, dotq = 6,11-dioxido-5,12-naphthacenedionato) and connected by two 2,4,6-tripyridin-4-yl-1,3,5-triazine (tpt) panels, which encapsulate the guest molecules 1-(4,6-dichloro-1,3,5-triazin-2-yl)pyrene and Pd(acac)(2), have been prepared. The host-guest properties of these water-soluble delivery systems were studied in solution by NMR and fluorescence spectroscopy, providing the stability constants (K) for these host-guest systems. Moreover, the ability of the hosts to deliver the guests into cancer cells was evaluated and the uptake mechanism studied; the rate of release of the guest molecule was found to depend on the portal size of the host.

  • Details
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Type
research article
DOI
10.1002/chem.201003530
Web of Science ID

WOS:000295001100018

Author(s)
Barry, Nicolas P. E.
Zava, Olivier  
Dyson, Paul J.  
Therrien, Bruno
Date Issued

2011

Published in
Chemistry - A European Journal
Volume

17

Start page

9669

End page

9677

Subjects

bioorganometallic chemistry

•

drug delivery

•

endocytosis

•

host-guest systems

•

ruthenium

•

Arene Ruthenium Complexes

•

Supramolecular Capsules

•

Anticancer Complexes

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Guest Exchange

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Phase-I

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Encapsulation

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Host

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Coordination

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Therapeutics

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Chemotherapy

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCOM  
Available on Infoscience
December 16, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/73556
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