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research article
Efficient characterization of high-dimensional parameter spaces for systems biology
2011
Background: A biological system's robustness to mutations and its evolution are influenced by the structure of its viable space, the region of its space of biochemical parameters where it can exert its function. In systems with a large number of biochemical parameters, viable regions with potentially complex geometries fill a tiny fraction of the whole parameter space. This hampers explorations of the viable space based on "brute force" or Gaussian sampling.
Type
research article
Web of Science ID
WOS:000295459000001
Authors
Publication date
2011
Published in
Volume
5
Start page
142
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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