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research article
In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition
2011
Background: Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has mainly been studied in brain slice preparations in vitro. Here, we investigate brain-state-dependent neocortical synaptic interactions in vivo by combining the specificity of optogenetic stimulation with the precision of whole-cell recordings from postsynaptic excitatory glutamatergic neurons and GFP-labeled inhibitory GABAergic neurons targeted through two-photon microscopy.
Type
research article
Web of Science ID
WOS:000295899600016
Authors
Mateo, Celine
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Zhang, Feng
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Deisseroth, Karl
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Publication date
2011
Publisher
Published in
Volume
21
Issue
19
Start page
1593
End page
1602
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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