We compare non-local magnetoresistance measurements in multi-terminal Ni nanostructures with corresponding local experiments. In both configurations, the measured voltages show the characteristic features of anisotropic magnetoresistance (AMR). However, the magnitude of the non-local AMR signal is up to one order of magnitude larger than its local counterpart. Moreover, the non-local AMR increases with increasing degree of non-locality, i.e., with the separation between the region of the main current flow and the voltage measurement region. All experimental observations can be consistently modeled in terms of current spreading in a non-isotropic conductor. Our results show that current spreading can significantly enhance the magnetoresistance signal in non-local experiments. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3640487]