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  4. A triplet spike-timing-dependent plasticity model generalizes the Bienenstock-Cooper-Munro rule to higher-order spatiotemporal correlations
 
research article

A triplet spike-timing-dependent plasticity model generalizes the Bienenstock-Cooper-Munro rule to higher-order spatiotemporal correlations

Gjorgjieva, Julijana
•
Clopath, Claudia
•
Audet, Juliette
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2011
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)

Synaptic strength depresses for low and potentiates for high activation of the postsynaptic neuron. This feature is a key property of the Bienenstock-Cooper-Munro (BCM) synaptic learning rule, which has been shown to maximize the selectivity of the postsynaptic neuron, and thereby offers a possible explanation for experience-dependent cortical plasticity such as orientation selectivity. However, the BCM framework is rate-based and a significant amount of recent work has shown that synaptic plasticity also depends on the precise timing of presynaptic and postsynaptic spikes. Here we consider a triplet model of spike-timing-dependent plasticity (STDP) that depends on the interactions of three precisely timed spikes. Triplet STDP has been shown to describe plasticity experiments that the classical STDP rule, based on pairs of spikes, has failed to capture. In the case of rate-based patterns, we show a tight correspondence between the triplet STDP rule and the BCM rule. We analytically demonstrate the selectivity property of the triplet STDP rule for orthogonal inputs and perform numerical simulations for nonorthogonal inputs. Moreover, in contrast to BCM, we show that triplet STDP can also induce selectivity for input patterns consisting of higher-order spatiotemporal correlations, which exist in natural stimuli and have been measured in the brain. We show that this sensitivity to higher-order correlations can be used to develop direction and speed selectivity.

  • Details
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Type
research article
DOI
10.1073/pnas.1105933108
Web of Science ID

WOS:000297463100058

Author(s)
Gjorgjieva, Julijana
Clopath, Claudia
Audet, Juliette
Pfister, Jean-Pascal  
Date Issued

2011

Publisher

National Academy of Sciences

Published in
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)
Volume

108

Start page

19383

End page

19388

Subjects

Long-Term Potentiation

•

Bidirectional Synaptic Plasticity

•

Natural Scene Environments

•

Visual-Cortex

•

Information-Transmission

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Direction Selectivity

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Binocular Interaction

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Orientation

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Depression

•

Neurons

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCN  
Available on Infoscience
December 16, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/73204
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