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research article

Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure

Michaelson, Jacob J.
•
Trump, Saskia
•
Rudzok, Susanne
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2011
BMC Genomics

Background: Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ("side effects"). Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals.

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Type
research article
DOI
10.1186/1471-2164-12-502
Web of Science ID

WOS:000296965300001

Author(s)
Michaelson, Jacob J.
Trump, Saskia
Rudzok, Susanne
Gräbsch, Carolin
Madureira, Danielle J.
Dautel, Franziska
Mai, Juliane
Attinger, Sabine
Schirmer, Kristin  
Von Bergen, Martin
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Date Issued

2011

Publisher

BioMed Central

Published in
BMC Genomics
Volume

12

Issue

1

Start page

502

Subjects

Aryl-Hydrocarbon Receptor

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Gene-Expression Data

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Time Biclustering Algorithm

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Human Cell-Lines

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Glucocorticoid-Receptor

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Diol Epoxide

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Ah Receptor

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Phase-I

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Series

•

Benzo(A)Pyrene

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
TOX  
Available on Infoscience
December 12, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/73091
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