Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure

• Published in: BMC Genomics (ISSN: 1471-2164), vol. 12, num. 1, p. 502
• BioMed Central, 2011

Background: Small molecule ligands often have multiple effects on the transcriptional program of a cell: they trigger a receptor specific response and additional, indirect responses ("side effects"). Distinguishing those responses is important for understanding side effects of drugs and for elucidating molecular mechanisms of toxic chemicals.

Keywords: Aryl-Hydrocarbon Receptor ; Gene-Expression Data ; Time Biclustering Algorithm ; Human Cell-Lines ; Glucocorticoid-Receptor ; Diol Epoxide ; Ah Receptor ; Phase-I ; Series ; Benzo(A)Pyrene

Reference

• EPFL-ARTICLE-170565
• doi:10.1186/1471-2164-12-502
• View record in Web of Science

Record created on 2011-12-12, modified on 2016-08-09