Functionalization of adhesion sites for cell attachment on a silicon microsystem

Mesenchymal Stem Cells (MSC) are multipotent adult stem cells that are predominantly obtained from the bone marrow. MSC have a high ability to differentiate into a multitude of cell types that are very attractive for tissue engineering. To study the effects of mechanical strain on this kind of cells, we have developed a silicon microsystem (see the photograph below). The main objective of this semester project will be to create functionalized adhesion sites for fibroblasts and MSC attachment on a silicon device. First, the student will have to find and test different methods which could be used to promote single-cell adhesion on silicon. Then, he will have to adapt this method to our system and perform preliminary tests with fibroblasts.


Advisor(s):
Hausherr, Tanja Cloé
Yamahata, Christophe
Pioletti, Dominique
Gijs, Martinus
Year:
2012
Keywords:
Note:
Main activities: Literature search, biological experiments, technology development, process optimization and characterization. This project will be conducted in collaboration between two laboratories: LMIS2 ( Dr. Christophe Yamahata) and LBO (Tanja Hausherr, Prof Dominique Pioletti). The work can be done in French or English.
Laboratories:


Note: The status of this file is: Involved Laboratories Only


 Record created 2011-11-24, last modified 2018-09-13

Photograph of the microactuator developed in the Laboratory of Microsystems and fabricated in the CMi clean room (size of the silicon chip: 7 mm × 9 mm).:
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Principle of the microsystem and schematic representation of the adhesion sites.:
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