Functionalization of adhesion sites for cell attachment on a silicon microsystem

Mesenchymal Stem Cells (MSC) are multipotent adult stem cells that are predominantly obtained from the bone marrow. MSC have a high ability to differentiate into a multitude of cell types that are very attractive for tissue engineering. To study the effects of mechanical strain on this kind of cells, we have developed a silicon microsystem (see the photograph below). The main objective of this semester project will be to create functionalized adhesion sites for fibroblasts and MSC attachment on a silicon device. First, the student will have to find and test different methods which could be used to promote single-cell adhesion on silicon. Then, he will have to adapt this method to our system and perform preliminary tests with fibroblasts.

Hausherr, Tanja Cloé
Yamahata, Christophe
Pioletti, Dominique
Gijs, Martinus
Main activities: Literature search, biological experiments, technology development, process optimization and characterization. This project will be conducted in collaboration between two laboratories: LMIS2 ( Dr. Christophe Yamahata) and LBO (Tanja Hausherr, Prof Dominique Pioletti). The work can be done in French or English.

Note: The status of this file is: Involved Laboratories Only

 Record created 2011-11-24, last modified 2018-09-13

Photograph of the microactuator developed in the Laboratory of Microsystems and fabricated in the CMi clean room (size of the silicon chip: 7 mm × 9 mm).:
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Principle of the microsystem and schematic representation of the adhesion sites.:
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