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review article
Calorie restriction: is AMPK a key sensor and effector?
Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the ability to transcriptionally reprogram the cell and metabolically adapt to external cues. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span.
Type
review article
Web of Science ID
WOS:000293829900002
Authors
Publication date
2011
Published in
Volume
26
Issue
4
Start page
214
End page
24
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 15, 2011
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