Investigation of protein aggregation dynamics with a Bloch surface wave sensor

We present a study of the dynamics of protein aggregation using a common path heterodyne Bloch surface wave sensing scheme. We demonstrate the ability to detect, during thermal incubation, the early events linked to the aggregation of proteins related to conformational diseases. Alzheimer's amyloid-β 1-42 is used to demonstrate the efficiency of the method. A model based on elementary interactions is shown to describe accurately the aggregation process. The described sensing scheme is sensitive to the early events of the aggregation process. is hence proposed as a method for the detection of early stages of the evolution of conformational diseases


Published in:
Proceedings of SPIE, 8090, 1
Presented at:
SPIE/OSA European Conferences on Biomedical Optics, Munich, Germany, May 22-26, 2011
Year:
2011
Publisher:
SPIE
ISSN:
1996-756X
Keywords:
Laboratories:




 Record created 2011-10-27, last modified 2018-03-17

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