The unique confinement of shock waves inside isolated liquid volumes amplifies the density of shock–liquid interactions. We investigate this universal principle through an interdisciplinary study of shock-induced cavitation inside liquid volumes, isolated in 2 and 3 dimensions. By combining high-speed visualizations of ideal water drops realized in microgravity with smoothed particle simulations, we evidence strong shock-induced cavitation at the focus of the confined shocks. We extend this analysis to ground-observations of jets and drops using an analytic model and argue that cavitation caused by trapped shocks offers a distinct mechanism of erosion in high-speed impacts (>rsim100ms-1).