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research article
Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-N-Anilides
2011
Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 degrees C. alpha-Iminocarboxamides, generated in situ from ketoamides, cyclized similarly to 3-aminooxindoles under identical conditions.
Type
research article
Web of Science ID
WOS:000295817100032
Authors
Publication date
2011
Published in
Volume
13
Issue
20
Start page
5536
End page
5539
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 20, 2011
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