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research article
Enantioselective construction of spirocyclic oxindolic cyclopentanes by palladium-catalyzed trimethylenemethane-[3+2]-cycloaddition
The palladium catalyzed [3+2] trimethylenemethane (TMM) cycloaddn. is an efficient method for the construction of cyclopentanes. Herein, a catalytic asym. protocol for the synthesis of spirocyclic oxindolic cyclopentanes, e.g., I, is reported. The title compds. were obtained in excellent yields and enantioselectivities. In this process, the chiral ligand controls the diastereo- as well as enantioselectivity, and the construction of up to three adjacent stereogenic centers.
Type
research article
Authors
Publication date
2007
Publisher
Published in
Volume
129
Start page
12396
End page
12397
Note
CAPLUS AN 2007:1052375(Journal)
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 17, 2011
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