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research article
Synthesis and biological activity of largazole and derivatives
A modular synthesis of the marine natural product largazole and related synthetic analogs is described. Largazole was prepd. in 10% overall yield through a synthetic route with a longest linear sequence of nine steps. Activity tests showed the necessity of the thiobutenyl moiety for antiproliferative activity.
Type
research article
Authors
Publication date
2008
Publisher
Published in
Volume
47
Start page
6483
End page
6485
Note
CAPLUS AN 2008:1047341(Journal)
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 17, 2011
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