Loading...
research article
Enantioselective rhodium-catalyzed C-C bond activations
2010
A review. The catalytic activation of C-C single bonds represents a major challenge in organometallic chem. Strained ring substrates occupy in this respect a privileged role as their inherent ring strain facilitates the desired metal insertion. Employing sym. substituted tert-cyclobutanols, an enantioselective Rh(ι)-catalyzed β-C elimination creates alkyl-Rh species bearing all-C quaternary stereogenic centers. Downstream reactions enable access to a wide range of synthetically versatile products such as substituted cyclohexenones, lactones and indanols with excellent enantioselectivities of up to 99% ee.
Type
research article
Authors
Publication date
2010
Publisher
Published in
Volume
64
Start page
153
End page
156
Subjects
Note
CAPLUS AN 2010:507839(Journal; General Review)
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 17, 2011
Use this identifier to reference this record