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research article
Rhodium-Catalyzed C-C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers
A rhodium-catalyzed enantioselective insertion into the C-C bond of tert-cyclobutanols and subsequent proto-demetalation provides access to Me substituted quaternary stereogenic centers in excellent yields and enantioselectivities. The reaction was used for a synthesis of (S)-4-ethyl-4-methyl-octane, the simplest satd. hydrocarbon with a quaternary stereogenic center.
Type
research article
Authors
Publication date
2010
Publisher
Published in
Volume
132
Start page
5340
End page
5341
Note
CAPLUS AN 2010:396037(Journal)
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 17, 2011
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