Rhodium-Catalyzed C-C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers

A rhodium-catalyzed enantioselective insertion into the C-C bond of tert-cyclobutanols and subsequent proto-demetalation provides access to Me substituted quaternary stereogenic centers in excellent yields and enantioselectivities. The reaction was used for a synthesis of (S)-4-ethyl-4-methyl-octane, the simplest satd. hydrocarbon with a quaternary stereogenic center.


Published in:
Journal of the American Chemical Society, 132, 5340-5341
Year:
2010
Publisher:
American Chemical Society
ISSN:
0002-7863
Keywords:
Note:
CAPLUS AN 2010:396037(Journal)
Laboratories:




 Record created 2011-08-17, last modified 2018-03-17


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