Rhodium-Catalyzed C-C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers
A rhodium-catalyzed enantioselective insertion into the C-C bond of tert-cyclobutanols and subsequent proto-demetalation provides access to Me substituted quaternary stereogenic centers in excellent yields and enantioselectivities. The reaction was used for a synthesis of (S)-4-ethyl-4-methyl-octane, the simplest satd. hydrocarbon with a quaternary stereogenic center.
CAPLUS AN 2010:396037(Journal)
Record created on 2011-08-17, modified on 2016-08-09