Application of an asymmetric flow field flow fractionation (AF4) multi-detector approach for metallic ENP characterization - prospects and limitations demonstrated on Au nanoparticles
In this work we discuss about the method development, applicability and limitations of an asymmetric flow field flow fractionation (A4F) system in combination with a multi-detector setup consisting of UV/vis, light scattering, and inductively coupled plasma mass spectrometry (ICPMS). The overall aim was to obtain a size dependent-, element specific-, and quantitative method appropriate for the characterization of metallic engineered nanoparticle (ENP) dispersions. Thus, systematic investigations of crucial method parameters were performed by employing well characterized Au nanoparticles (Au-NPs) as a defined model system.
Keywords: Asymmetric flow field flow fractionation ; Light scattering ; Icpms ; Metallic engineered nanoparticles ; Au nanoparticles ; Particle-membrane interaction ; Plasma-Mass Spectrometry ; Size ; Colloids ; Nanomaterials ; Cytotoxicity ; Environment ; Particles ; Release ; Facades ; Icpms
Record created on 2011-08-10, modified on 2016-10-04