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research article
Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
2011
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs.
Type
research article
Web of Science ID
WOS:000290787100014
Authors
Coste, Gerald
•
Horlacher, Tim
•
Molina, Lidia
•
Moreno-Vargas, Antonio J.
•
•
Robina, Inmaculada
•
Seeberger, Peter H.
•
Publication date
2011
Published in
Start page
1759
End page
1770
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
June 17, 2011
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