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research article

Application of Supramolecular Nanostamping to the Replication of DNA Nanoarrays

Akbulut, Ozge
•
Jung, Jin-Mi
•
Bennett, Ryan D.
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2007
Nano Letters

The rapid development of molecular biology is creating a pressing need for arrays of biomolecules that are able to detect smaller and smaller volumes of analytes. This goal can be achieved by shrinking the average size and spacing of the arrays constituent features. While bioarrays with dot size and spacing on the nanometer scale have been successfully fabricated via scanning probe microscopy-based techniques, such fabrication methods are serial in nature and consequently slow and expensive. Additionally, the development of truly small arrays able to analyze scarce volumes of liquids is hindered by the present use of optical detection, which sets the minimum dot spacing on the order of roughly half the excitation wavelength. Here, we show that supramolecular nanostamping, a recently introduced truly parallel method for the stamping of DNA features, can efficiently reproduce DNA arrays with features as small as 14 +/- 2 nm spaced 77 +/- 10 nm. Moreover, we demonstrate that hybridization of these nanoarrays can be detected using atomic force microscopy in a simple and scaleable way that additionally does not require labeling of the DNA strands.

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Type
research article
DOI
10.1021/nl0720758
Author(s)
Akbulut, Ozge
Jung, Jin-Mi
Bennett, Ryan D.
Hu, Ying
Jung, Hee-Tae
Cohen, Robert E.
Mayes, Anne M.
Stellacci, Francesco  
Date Issued

2007

Publisher

American Chemical Society (ACS)

Published in
Nano Letters
Volume

7

Issue

11

Start page

3493

End page

3498

Subjects

DIP-PEN NANOLITHOGRAPHY

•

NANOFABRICATION

•

CLUSTERS

•

SURFACES

•

PROBES

•

ARRAY

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SUNMIL  
Available on Infoscience
June 6, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/68417
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