High-Performance Protein Preconcentrator Using Microchannel-Integrated Nafion Strip

A microfluidic device for protein preconcentration based on the electrokinetic trapping principle is proposed. It comprises a Nafion strip which is simply cut from a commercially available membrane and integrated into a polydimethylsiloxane (PDMS) microfluidic structure using a guiding channel. By applying low voltage (<15 V), the device exhibits a preconcentration factor of >1000 of fluorescently labeled bovine serum albumin (BSA) within a few minutes. Moreover, a numerical study of the preconcentration effect is presented to microscopically understand the phenomenon in our type of device.


Published in:
Proceedings of the 16th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 238-241
Presented at:
The 16th International Conference on Solid-State Sensors, Actuators and Microsystems, Beijing, China, June 5-9, 2011
Year:
2011
Publisher:
IEEE
Keywords:
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 Record created 2011-06-01, last modified 2018-03-17

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