ProPhyC: a probabilistic phylogenetic model for refining regulatory networks
The experimental determination of transcriptional regulatory networks in the laboratory remains difficult and time-consuming, while computational methods to infer these networks provide only modest accuracy. The latter can be attributed in part to the limitations of a single-organism approach. Computational biology has long used comparative and, more generally, evolutionary approaches to extend the reach and accuracy of its analyses. We therefore use an evolutionary approach to the inference of regulatory networks, which enables us to study evolutionary models for these networks as well as to improve the accuracy of inferred networks.
WOS:000296688700033
2011
Lecture Notes in Computer Science; 6674
344
357
REVIEWED
Event name | Event place | Event date |
China | May 2011 | |