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research article
Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
2010
In a genome-wide association study of patients being treated for chronic hepatitis C, 2 functional variants in ITPA that cause inosine triphosphatase (ITPase) deficiency were shown to protect against ribavirin (RBV)-induced hemolytic anemia during early stages of treatment. We aimed to replicate this finding in an independent cohort from the Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C and to investigate the effects of these variants beyond week 4.
Type
research article
Authors
Thompson, Alexander J.
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Patel, Keyur
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Tillmann, Hans L.
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Naggie, Susanna
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Ge, Dongliang
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Urban, Thomas J.
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Shianna, Kevin V.
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Muir, Andrew J.
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Fried, Michael W.
Publication date
2010
Published in
Volume
139
Issue
4
Start page
1181
End page
9
Subjects
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 11, 2011
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