Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function
Hitomi, Yuki; Cirulli, Elizabeth T.; Fellay, Jacques; McHutchison, John G.; Thompson, Alexander J.; Gumbs, Curtis E.; Shianna, Kevin V.; Urban, Thomas J.; Goldstein, David B.
2011

Abstract

Genetic variation of inosine triphosphatase (ITPA) causing an accumulation of inosine triphosphate (ITP) has been shown to protect patients against ribavirin (RBV)-induced anemia during treatment for chronic hepatitis C infection by genome-wide association study (GWAS). However, the biologic mechanism by which this occurs is unknown.

Details

Title Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function
Author(s) Hitomi, Yuki ; Cirulli, Elizabeth T. ; Fellay, Jacques ; McHutchison, John G. ; Thompson, Alexander J. ; Gumbs, Curtis E. ; Shianna, Kevin V. ; Urban, Thomas J. ; Goldstein, David B.
Published in Gastroenterology
Volume 140
Issue 4
Pages 1314-21
Date 2011
ISSN 1528-0012
DOI https://doi.org/10.1053/j.gastro.2010.12.038
Laboratories GR-FE
Record Appears in Scientific production and competences > SV - School of Life Sciences > GHI - Global Health Institute > GR-FE - Fellay Group
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2011-04-11