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research article
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function
2011
Genetic variation of inosine triphosphatase (ITPA) causing an accumulation of inosine triphosphate (ITP) has been shown to protect patients against ribavirin (RBV)-induced anemia during treatment for chronic hepatitis C infection by genome-wide association study (GWAS). However, the biologic mechanism by which this occurs is unknown.
Type
research article
Authors
Hitomi, Yuki
•
Cirulli, Elizabeth T.
•
•
McHutchison, John G.
•
Thompson, Alexander J.
•
Gumbs, Curtis E.
•
Shianna, Kevin V.
•
Urban, Thomas J.
•
Goldstein, David B.
Publication date
2011
Published in
Volume
140
Issue
4
Start page
1314
End page
21
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 11, 2011
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