Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function

Genetic variation of inosine triphosphatase (ITPA) causing an accumulation of inosine triphosphate (ITP) has been shown to protect patients against ribavirin (RBV)-induced anemia during treatment for chronic hepatitis C infection by genome-wide association study (GWAS). However, the biologic mechanism by which this occurs is unknown.


Published in:
Gastroenterology, 140, 4, 1314-21
Year:
2011
ISSN:
1528-0012
Laboratories:




 Record created 2011-04-11, last modified 2018-03-17


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