High-resolution MEA platform for in-vitro elecrogenic cell networks imaging

• Presented at: 29th Annual International Conference of the IEEE EMBS, Lyon, France, August 23-26, 2007
• Published in: Proceedings of the 29th Annual International Conference of the IEEE EMBS, p. 6085-6088
• Publication date: 2007

Abstract—A platform based on an active-pixel-sensor electrode array (APS-MEA) for high-resolution imaging of invitro electrogenic cell cultures is presented, characterized and validated under culture conditions. The system enables full frame acquisition at 8 kHz from 4096 microelectrodes integrated with separations of 21 μm and zoomed area acquisition with temporal resolutions down to 8 μs. This bimodal acquisition feature opens new perspectives in particular for neuronal activity analysis and for the correlation of microscale and macro-scale behaviors. The low-noise performances of the integrated amplifier (11 μVRMS) combined with a hardware implementation reflecting image-/video-concepts enable high-resolution acquisitions with real-time processing capabilities adapted to the handling of the large amount of acquired data.

Reference

• EPFL-CONF-164780

Record created on 2011-04-11, modified on 2017-05-10