000164420 001__ 164420
000164420 005__ 20190604054627.0
000164420 02470 $$2ISI
000164420 0247_ $$2doi$$a10.1021/ac103118r
000164420 02470 $$a000288182900050
000164420 037__ $$aARTICLE
000164420 245__ $$aLink between Alginate Reaction Front Propagation and General Reaction Diffusion Theory
000164420 269__ $$a2011
000164420 260__ $$c2011
000164420 336__ $$aJournal Articles
000164420 520__ $$aWe provide a common theoretical framework reuniting specific models for the Ca2+-alginate system and general reaction diffusion theory along with experimental validation on a microfluidic chip. As a starting point, we use a set of nonlinear, partial differential equations that are traditionally solved numerically: the Mikkelsen−Elgsaeter model. Applying the traveling-wave hypothesis as a major simplification, we obtain an analytical solution. The solution indicates that the fundamental properties of the alginate reaction front are governed by a single dimensionless parameter λ. For small λ values, a large depletion zone accompanies the reaction front. For large λ values, the alginate reacts before having the time to diffuse significantly. We show that the λ parameter is of general importance beyond the alginate model system, as it can be used to classify known solutions for second-order reaction diffusion schemes, along with the novel solution presented here. For experimental validation, we develop a microchip model system, in which the alginate gel formation can be carried out in a highly controlled, essentially 1D environment. The use of a filter barrier enables us to rapidly renew the CaCl2 solution, while maintaining flow speeds lower than 1 μm/s for the alginate compartment. This allows one to impose an exactly known bulk CaCl2 concentration and diffusion resistance. This experimental model system, taken together with the theoretical development, enables the determination of the entire set of physicochemical parameters governing the alginate reaction front in a single experiment.
000164420 6531_ $$aGelation
000164420 700__ $$0240218$$g157067$$aBraschler, Thomas
000164420 700__ $$0242543$$g178347$$aValero, Ana
000164420 700__ $$0242544$$g180080$$aColella, Ludovica
000164420 700__ $$0240330$$g165951$$aPataky, Kristopher
000164420 700__ $$g145781$$aBrugger, Jürgen$$0240120
000164420 700__ $$0240219$$g107144$$aRenaud, Philippe
000164420 773__ $$j83$$tAnalytical Chemistry$$k6$$q2234-2242
000164420 8564_ $$uhttps://infoscience.epfl.ch/record/164420/files/Braschler%27AnalChem2011.pdf$$zn/a$$s1904226$$yPublisher's version
000164420 909C0 $$xU10324$$0252064$$pLMIS4
000164420 909C0 $$pLMIS1$$xU10321$$0252040
000164420 909CO $$qGLOBAL_SET$$pSTI$$particle$$ooai:infoscience.tind.io:164420
000164420 917Z8 $$x113143
000164420 937__ $$aEPFL-ARTICLE-164420
000164420 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000164420 980__ $$aARTICLE