Solution for diagnosing or treating tissue pathologies
The invention concerns a 5-aminolevulinic acid ester (I) soln. for producing a pharmaceutical prepn. useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followed, in the case of diagnosis, by detection of fluorescent protoporphyrin IX (II). The I concn. in said soln. is less than 1% and ranges between 0.01% and 0.5%. Said low I concn. in the soln. increases II synthesis and homogenizes its distribution in the cell layers while highly reducing the secondary toxicity for the treated cells (no data).
Keywords: 106-60-5D (5-Aminolevulinic acid); 140898-97-1 (Hexyl 5-Aminolevulinate) Role: BAC (Biological activity or effector ; except adverse) ; BSU (Biological study ; unclassified) ; THU (Therapeutic use) ; BIOL (Biological study) ; USES (Uses) (soln. for diagnosing ; pharmaceutical soln diagnosis treatment tissue pathol
Copyright 2003 ACS
written in French.
Buffers; Disease; Radiation; Solvents (soln. for diagnosing or treating tissue pathologies); Alcohols Role: NUU (Other use, unclassified), USES (Uses) (soln. for diagnosing or treating tissue pathologies); Drug delivery systems (solns.; soln. for diagnosing or treating tissue pathologies)
Designated States W: CA, JP, US.
Designated States RW: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE.
Thomas, P; Phototherapie Dynamique Topique 1996, 15, 407|Chang, S; Journal of Photochemistry and Photobiology B Biology 1997, 38, 114
Record created on 2011-02-01, modified on 2016-08-09